Drive issue or something else?

" The laptop this is on is a Dell Inspiron 3521"

By the way, I'm assuming windows 10 is on the system....

Also,

Please check and see if the hard drive is listed in the BIOS. Power on system, quickly start tapping the F2 key continuously until to see the BIOS setup.

If there isn't any error code and the hard drive is detected in the BIOS:

Installing drivers through Windows Update - Type Setting onto [Cortana] search box, click Update And Security, and select "Check for Updates". Install any available updates and restart your PC if required. Please don't wait later to install, select Restart Now. 

If the problem still isn't fix:

Run Guide Me option in your Dell Product Support page. The tool will automatically detect (Audio, Chipset, Video) driver updates for the system. Please follow instructions to run Guide Me option in link below.

How to Find Drivers and Update Them (Official Dell Tech ...

Then on power on, it says there's no boot disk. I did the Dell Diags and everything shows good.

:emotion-2:

I like to suggest you run the Pre-Boot System Assessment (PSA) Diagnostics to check hardware on system by following the steps below.

1. Power off the system. Remove all peripherals except AC adapter

2. Power on system, quickly start tapping the F12 continuously until you see Preparing one time boot menu in the top right corner of the screen. In the boot menu, stroll down to Diagnostic and then click on it.  After quick tests, click on Hard drive, and select Thorough Test Mode. Run Video Card and Memory as well.

I made sure all the updates and drivers were up to date and they were.

Everything checked out fine, no issues.

Yes, Windows 10 1703.

You check to see if the hard drive (or solid state drive) is detected in the BIOS?

It appears to be. BIOS doesn't look like what I'm used to.

BSOD screen...

http://tinypic.com/r/24fcndd/9

BIOS settings pics...

http://tinypic.com/r/1fe4g8/9
http://tinypic.com/r/iwrn85/9
http://tinypic.com/r/25zh7pv/9
http://tinypic.com/r/16hnork/9

There's a "Stop Code: Memory Management" error code on the blue screen image

Under the main tab in the BIOS, the hard drive (ST500L TO12 9WS142) is listed but doesn't have a lot of storage space on it - 500GB).  Do you back up most of your documents, photos, music , videos and other important stuff to a external drive or some type of backup software?  Please type File Explorer or click the yellow folder at the bottom of taskbar, click This PC, and then verify the amount of storage space on the C drive. For example:

Dell Inspiron 3543, windows 10 - 1000GB storage space. As you can see below, the C dive  

I saw it said "Stop Code: Memory Management". If I could I'd post dmp file details but there is never one created after a bsod with my settings below or automatic dumps...

Here's what I got...

Dell Inspiron 3521, Windows 10 Home - 500GB storage space. Yes I backup to a WD 3TB external USB drive using WD Smartware.

I've also ran the Windows Memory Diagnostic and it said there were no issues.

Fifth - Uninstall any unnecessary programs in Apps & features or Programs & features. Type Setting onto search box, select Apps.  I also suggest turning off any unnecessary Apps running in the background. Setting> Privacy > background Apps 

Type Setting onto search box, select System, Storage and then click on drive. You could see which programs are eating up your storage space.