Lost Function of Mouse and Keyboard

New Aurora R5 with Windows 10 Pro (3 weeks old).  Was using the computer with both mouse and keyboard (bluetooth) and then they both stopped functioning.  Tried attaching the wired Alienware wired mouse and keyboard.  Still no function.  Believe the computer is not frozen cause each time I reboot I can see the Cloud app signaling it is syncing.

Have tried to enter bios by pressing the F2 key as well as restarting and trying the F12 key when the Alien head appears (tried holding it down continuously and tried tapping the key repeatedly, neither worked.  There is advice on the Dell sight to wait for the Alien Head and the F2 or F12 key to appear before pressing the key but my computer does not show a key - just the logo "Alienware" with the Head.  The guidance is aimed at Windows 7 and 8.  Not clear what the guidance for Windows 10 would be...).

Had created an Emergency Boot Disk on a thumb drive.  Tested it after it was made to ensure it would boot - it did.  Tried it in this situation and it does not.

Have tried repositioning the usb mice and keyboards to various ports on front and back.  None work.  Have pulled them out while the system is on to see if I get the notice to eject the usb device correctly.  Do not get any messages of this sort.  Also did this with my USB back-up hard drive.  No notice.

Not sure what to do next.  Help!