Realtek Audio Crackling Since Motherboard Replacement

My motherboard recently died unexpectedly, after my PC was no longer under warranty. Since this motherboard is no longer commercially available from Dell, I had to purchase a replacement via third-party. It's the same model of motherboard, but since I replaced it, my audio is crackling to varying degrees, whether I use my monitors running through my PreSonus Audiobox 22VSL interface, headphones directly connected to the PC with the PreSonus unplugged, or headphones connected to the PreSonus USB audio interface.

The entire reason I purchased a Dell XPS is to use it for a music recording station. I tried repeatedly uninstalling/reinstalling the Realtek audio driver using the driver from the Dell website for my specific PC, but the issue persists. I read elsewhere that installing the High Definition audio driver can help, but this errors out (error 0001) every time I try to complete the installation. Uninstalling the Realtek driver, rebooting, and then trying to install the HD audio driver resulted in the same error. Uninstalling and reinstalling the drivers for my USB audio interface didn't help. Sometimes it sounds a bit better after a reboot, but overwhelmingly not (and the sound is never perfect, even for a bit). Windows Audio Troubleshooter is no help, and the issue happens regardless of which application is making sound.

Any help or suggestions are greatly appreciated.