PowerPath rebootless re-bootless no reboot options hacks questions.

Installing PowerPath; Is it possible to reconfigure a host without performing a reboot. I am rezoning a bunch of servers to some new switches and would prefer not rebooting as these are production servers. The outage process is tedious to say the least. I've never managed to find a solution to performing a reconfiguration or new installation of PowerPath without rebooting a server. Is it possible? Does anyone have any tricks or hacks to make this re-bootless on certain occasions?

Thanks Much