Monitor or gfx card issue

Good evening,

I have a grey rectangle that appears in the upper left corner of my screen when I using video games.  It is most noticeable on white backgrounds.  I am attaching a picture take from my phone during the loading screen of Steamworld Heist.  I have also noticed this in Witcher 3 and World of Warcraft.  

When doing a screen capture via F12 in Steam app it does not show the rectangle.  This makes me believe that it could possibly be a monitor issues.  Then again when running Chrome it doesn't show up so maybe it is graphic card related.

I have an Alienware R17 with a 1080GTX.  I have just updated my graphics drivers and I am still having the issue.

Thanks.