Gray box in upper left corner of screen

Good evening,

I am getting a gray box that is more noticeable on white backgrounds in the upper left corner of my screen.  It only happens while in game applications.  For example the the screen shot is from Steamworld Heist.  I have also seen then in Witcher 3 however less noticeable with the darker colors.  I have also seen in it World of Warcraft so it is not Steam specific.  It does not show when in Chrome or when no programs are running.

If I take a screenshot using F12 via the Steam shortcut key the box does not appear.  Even if it was displayed on the screen.

Would this be a monitor issue or would this be a driver issues?  I have an Alienware R17 with 1080gtx and the UHD monitor.

I am not sure when it actually started but its a once its been seen it can't be unseen kind of issue.

Thanks,

Joel